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Chronic diseases are considered as one of the serious concerns and threats to public health across the globe. Diseases such as chronic diabetes mellitus (CDM), cardio vasculardisease (CVD) and chronic kidney disease (CKD) are major chronic diseases responsible for millions of death. Each of these diseases is considered as a risk factor for the other two diseases. Therefore, noteworthy attention is being paid to reduce the risk of these diseases. A gigantic amount of medical data is generated in digital form from smart healthcare appliances in the current era. Although numerous machine learning (ML) algorithms are proposed for the early prediction of chronic diseases, these algorithmic models are neither generalized nor adaptive when the model is imposed on new disease datasets. Hence, these algorithms have to process a huge amount of disease data iteratively until the model converges. This limitation may make it difficult for ML models to fit and produce imprecise results. A single algorithm may not yield accurate results. Nonetheless, an ensemble of classifiers built from multiple models, that works based on a voting principle has been successfully applied to solve many classification tasks. The purpose of this paper is to make early prediction of chronic diseases using hybrid generative regression based deep intelligence network (HGRDIN) model.

In the proposed paper generative regression (GR) model is used in combination with deep neural network (DNN) for the early prediction of chronic disease. The GR model will obtain prior knowledge about the labelled data by analyzing the correlation between features and class labels. Hence, the weight assignment process of DNN is influenced by the relationship between attributes rather than random assignment. The knowledge obtained through these processes is passed as input to the DNN network for further prediction. Since the inference about the input data instances is drawn at the DNN through the GR model, the model is named as hybrid generative regression-based deep intelligence network (HGRDIN).

The credibility of the implemented approach is rigorously validated using various parameters such as accuracy, precision, recall, F score and area under the curve (AUC) score. During the training phase, the proposed algorithm is constantly regularized using the elastic net regularization technique and also hyper-tuned using the various parameters such as momentum and learning rate to minimize the misprediction rate. The experimental results illustrate that the proposed approach predicted the chronic disease with a minimal error by avoiding the possible overfitting and local minima problems. The result obtained with the proposed approach is also compared with the various traditional approaches.

Usually, the diagnostic data are multi-dimension in nature where the performance of the ML algorithm will degrade due to the data overfitting, curse of dimensionality issues. The result obtained through the experiment has achieved an average accuracy of 95%. Hence, analysis can be made further to improve predictive accuracy by overcoming the curse of dimensionality issues.

The proposed ML model can mimic the behavior of the doctor's brain. These algorithms have the capability to replace clinical tasks. The accurate result obtained through the innovative algorithms can free the physician from the mundane care and practices so that the physician can focus more on the complex issues.

Utilizing the proposed predictive model at the decision-making level for the early prediction of the disease is considered as a promising change towards the healthcare sector. The global burden of chronic disease can be reduced at an exceptional level through these approaches.

In the proposed HGRDIN model, the concept of transfer learning approach is used where the knowledge acquired through the GR process is applied on DNN that identified the possible relationship between the dependent and independent feature variables by mapping the chronic data instances to its corresponding target class before it is being passed as input to the DNN network. Hence, the result of the experiments illustrated that the proposed approach obtained superior performance in terms of various validation parameters than the existing conventional techniques.